responsables de las agudizaciones producen enzimas bacterianas capaces de Entre los antibióticos que no son destruidos por betalactamasas se. incluyen: enzimas que hidrolizan la droga, expulsión hidrolítica de la enzima renal dehidropeptidasa . las betalactamasas: uno se basa en la secuencia de. Learn more about Infección por betalactamasa de espectro extendido at Las enzimas hacen resistentes a las bacterias contra muchos tipos de antibióticos.

Author: Mikree Samukree
Country: Brazil
Language: English (Spanish)
Genre: Education
Published (Last): 10 July 2009
Pages: 298
PDF File Size: 18.85 Mb
ePub File Size: 19.35 Mb
ISBN: 975-1-55212-265-3
Downloads: 81677
Price: Free* [*Free Regsitration Required]
Uploader: Kazraktilar

Rodrigo Elisandro Mendes, Ph. Increase isolation of Gram-negative bacilli resistant to broad-spectrum cephalosporin has been observed during the last few years, thus betalactamasxs the use of more potent b -lactams, such as carbapenems.

The use of these antimicrobial agents may lead to the emergence of carbapenem resistant Gram-negative bacilli in the nosocomial environment.

Carbapenem resistance may be due to the production of Ambler class D b -lactamase or Ambler class B b -lactamase, also called metallo- b -lactamase M b L. Apart from the monobactam aztreonam, this class of enzyme virtually hydrolyze all the commercially available b -lactams. Since 90s, several clinical important nosocomial microorganisms, including members of Enterobacteriaceae family, Betalactxmasas spp.

When these carbapenem non-susceptible strains are found, they may be submitted to phenotypic M b L detection test in the microbiology laboratory in order to help infection control practioners and prevent the M b L gene dissemination, once these genes are embedded in mobile genetic elements, which can spread rapidly to other Gram-negative species.

Gram-negative bacilli, Carbapenem resistance, Metallo- b -lactamase, Integron, Gene cassette.

Atualmente, amostras bacterianas de P. Epidemiologia das metal- b -lactamases. O primeiro relato de M b L adquirida ocorreu em 46quando foi descrita uma nova subclasse denominada IMP O primeiro relato de uma M b L no continente americano ocorreu em por Gibb et al. Posteriormente, a mesma parceria avaliou cinco cepas de P. Epidemiologia das metalo- b -lactamases betallactamasas Brasil. Mais tarde, emuma variante de IMP foi relatada por Gales et al.

Esses autores descreveram o achado de uma cepa de A. Como descrito anteriormente, SPM-1 foi detectada betalactajasas amostra bacteriana de P. A classe 1 tem sido extensivamente estudada, e membros dela foram originalmente descritos como integrons.

Em estudo realizado por Arakawa et al. Em estudo posterior realizado por Lee et al. Uma cepa sabidamente produtora de M b L, tal qual a cepa P. Antimicrob Agents Chemotherv. Convenient test for screening metallo- b -lactamase-producing gram-negative bacteria by using thiol compounds. J Clin Microbiolv. Plasmid location and molecular heterogeneity of the L1 and L2 b -lactamase genes of Stenotrophomonas maltophilia.

J Antimicrob Chemotherv. Integrons and gene cassettes: OXA, a novel class D b -lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain. Clin Infect Disv. A functional classification scheme for b -lactamases and its correlation with molecular structure. Molecular characterization of a beta-lactamase gene, bla GIM-1encoding a new subclass of metallo- b -lactamase.


IMP-4, a novel metallo- b -lactamase from nosocomial Acinetobacter spp. Perfomance standards for antimicrobial susceptibility testing. Site-specific insertion of gene cassettes into integrons.

Mol Microbiolv. Site-specific deletion and rearrangement of integron insert genes catalyzed by the integron DNA integrase. J Bacteriolv. Expression of antibiotic resistance genes in the integrated cassettes of integrons. Characterization betalavtamasas the class 3 integron and the site-specific recombination system it determines. Integron-encoded IntI integrases preferentially recognize the adjacent betalctamasas attI site in recombination with a be site.

Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo- b -lactamase, in a tertiary care center in Cali, Colombia.

Overexpression, purification and characterization of the cloned metallo- b -lactamase L1 from Stenotrophomonas maltophilia. Antimicrob Agents Chemother, v. Molecular characterization of bla IMP-5a new integron-borne metallo- b -lactamase gene from an Acinetobacter baumannii nosocomial isolate in Portugal. IMP, a new plasmid-encoded metallo- b -lactamase from a Pseudomonas putida clinical isolate.

Dissemination in distinct Brazilian regions of an epidemic carbapenem-resistant Pseudomonas aeruginosa producing SPM metallo- b -lactamase. J Antimicrob Chemother, v. Emergence of an IMP-like metallo-enzyme in an Acinetobacter baumannii clinical strain from a Brazilian teaching hospital. Diagn Microbiol Infect Disv. IMP-1 producing Klebsiella pneumoniae outbreak in a brazilian teaching hospital. Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA of Acinetobacter baumannii.

Amino acid substitutions in a variant of IMP-1 metallo- b -lactamase. Detection of a variant metallo- b -lactamase, IMP, from two unrelated strains of Pseudomonas aeruginosa and an Alcaligenes xylosoxidans strain. enzimad

Infección por betalactamasa de espectro extendido | The Allen Clinic

First detection of a carbapenem-hydrolyzing metalloenzyme in an Enterobacteriaceae isolate in France. Cloning and characterization of bla VIMa new integron-borne metallo- b -lactamase gene from a Pseudomonas aeruginosa clinical isolate. Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo- b -lactamase-producing isolates of Pseudomonas spp. Novel acquired metallo- b -lactamase gene, bla SIM-1in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea.

First isolation of metallo- b -lactamase-producing multiresistant Klebsiella pneumoniae from a patient in Brazil. Of Pseudomonasporins, pumps and carbapenems. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: The Aeromonas hydrophila cphA gene: Biochemical characterization of the acquired metallo- b -lactamase SPM-1 from Pseudomonas aeruginosa.


Molecular characterization of an enterobacterial metallo- b -lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. Characterization and movement of the class 1 integron known as Tn and Tn Definition of the attI1 site of class 1 integrons.

Pseudomonas aeruginosa strains harbouring an unusual bla VIM-4 gene cassette isolated from hospitalized children in Poland Occurrence of a multidrug-resistant Pseudomonas aeruginosa clone in different hospitals in Rio de Janeiro, Brazil. J Clin Microbiol, v. Characterization of class 1 integrons from Pseudomonas aeruginosa that contain the bla VIM-2 carbapenem-hydrolyzing b -lactamase gene and of two novel aminoglycoside resistance gene cassettes.


Molecular analysis of metallo- b -lactamase gene bla SPM-1 -surrounding sequences from disseminated Pseudomonas aeruginosa isolates in Recife, Brazil. OXA, a novel class D b -lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Characterization of VIM-2, a carbapenem-hydrolyzing metallo- b -lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France. Acquired carbapenem-hydrolyzing b -lactamases and their genetic support.

Curr Pharm Biotechnolv. First isolation of a carbapenem-hydrolyzing b -lactamase in Pseudomonas aeruginosa in Spain.

Infección por betalactamasa de espectro extendido

Characterization of In, a new integron carrying a metallo- b -lactamase and a carbenicillinase, from Pseudomonas aeruginosa. Origins of the mobile gene cassettes found in integrons.

Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo- b -lactamase from different Italian hospitals. Characterization and sequence of the Chryseobacterium Flavobacterium meningosepticum carbapenemase: Biochem Jv.

A novel metallo- b -lactamase, Mbl1b, produced by the environmental bacterium Caulobacter crescentus. FEBS Lettv. Novel mechanism of hydrolysis of therapeutic b -lactams by Stenotrophomonas maltophilia L1 metallo- b -lactamase.

J Biol Chemv. A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: Dissemination of IMP-1 metallo- b -lactamase-producing Acinetobacter species in a Brazilian teaching hospital.

Infect Control Fnzimas Epidemiol Genetic characterization of betalactamasass novel metallo- b -lactamase gene, bla IMPharboured by a novel Tn -type transposon disseminating carbapenemase genes in Europe: Italian metallo- b -lactamases: Considerations in control and treatment of nosocomial infections due to multidrug-resistant Acinetobacter baumannii.

Evaluation of a new Etest for detecting metallo- b -lactamases in routine clinical testing. Enzyme kinetics and biochemical analysis of ImiS, the metallo- b -lactamase from Aeromonas sobria a. Nucleotide and amino acid sequences of the metallo- b -lactamase, ImiS, from Aeromonas veronii bv. Carbapenemases of Chryseobacterium Flavobacterium meningosepticum: Comparison of the double-disk, combined disk and Betaladtamasas methods for detecting metallo- b -lactamases in gram-negative bacilli.

Plasmid-encoded metallo- b -lactamase IMP-6 conferring resistance to carbapenems, especially meropenem. Molecular characterization of metallo- b -lactamase-producing Acinetobacter baumannii and Acinetobacter genomospecies 3 from Korea: All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Services on Demand Journal.